January 2, 2021

photoacoustic raman scattering

Normal electronic (and vibronic) Raman scattering. By Mirela M. Barsan (2103418), Ian S. Butler (594292), Denis F. R. Gilson (2103412), Ralph O. Moyer (2103415), Wei Zhou (24328), Hui Wu (219526) and Terrence J. Udovic (1272093) Cite . Normal pure vibrational Raman scattering. However, ther e are controversies on the identification of modes [20-21]. Two coherent beams 15, 17 of monochromatic radiation are directed through a sample of material. Units and orders of magnitude. Photoacoustic Raman spectroscopy Download PDF Info Publication number US4269509A. This dual modal probe is prepared by doping a semiconducting conjugated polymer with polydopamine (PDA) through a one-pot reaction. A 1-ns pulse width ytterbium-doped fiber laser is coupled into a single-mode polarization maintaining fiber. It is important, since, unlike spontaneous Raman scattering spectroscopy, which provides with the whole vibrational spectrum for a single wavelength excitation, stimulated Raman scattering excitation is limited to a single vibrational line. Ultrasound detection provides a simple way to discriminate against laser-induced breakdown and allows for the quantification of the stimulated Raman scattering process where direct optical detection is not available. Lipidrich tissue, such as atherosclerotic plaques and myelinated nerve fibers, exhibits an optical absorption peak near 1210 nm. However, the fixed 532 nm output is not suitable for spectroscopic PAM. Owing to its high chemical specificity and noninvasive detection capability, Raman scattering has been widely employed in cancer screening, diagnosis, and intraoperative surgical guidance in the past ten years. The Raman scattering amplification associated with this phenomenon is known as surface-enhanced Raman scattering (SERS) spectroscopy . In the apparatus, a molecular vibrational mode is excited by the SRS process. The development of a stimulated Raman scattering photoacoustic (SRS-PA) spectrometer is presented. Owing to much weaker acoustic scattering in tissues as compared to optical scattering, photoacoustic detection of harmonic molecular vibration has enabled significant improvement in imaging depth. An open-cell system is described and the performance criteria for practical photoacoustic instrumentation are discussed. Abstract: Photoacoustic microscopy (PAM) provides excellent image contrast based on optical absorption. Raman scattering efficiency can be enhanced by factors >10 8 when a substance is adsorbed on or near rough metal surfaces. Vibrational resonance Raman scattering. Photoacoustic spectroscopy is the measurement of the effect of absorbed electromagnetic energy (particularly of light) on matter by means of acoustic detection. Electronic (and vibronic) resonance Raman scattering. Raman, FTIR, Photoacoustic-Infrared, and Inelastic Neutron Scattering Spectra of Ternary Metal Hydride Salts A2MH5, (A = Ca, Sr, Eu; M = Ir, Rh) and Their Deuterides . References In vivo evaluation of HA‐4‐ATP‐AuNFs‐DOX on tumor‐bearing xenografts demonstrates its high efficacy in eradication of solid tumors in NIR‐II under PA–Raman dual image‐guided photo‐chemotherapy. Share sensitive information only on official, secure websites. A tuning mechanism 14 adjusts the frequency difference between the radiation beams 15, 17 to equal substantially the vibrational … The molecular population at this excited level will be reduced by the subsequent collision-induced vibrational relaxation. To monitor PB NPs from the background tissue in vivo, we also developed a new 700-nm-region stimulated Raman scattering (SRS) source (pulse energy up to 200 nJ and repetition rate up to 50 kHz) and implemented optical-resolution photoacoustic microscopy (OR-PAM). Photoacoustic Raman spectroscopy . infrared absorption or Raman scattering, the imaging depth is limited to the ballistic photon mean free path, which is a few hundred microns in a biological sample. The theory for generation of photoacoustic signals from stimulated Raman scattering is outlined, and vibration-rotation Raman spectra for CO 2 and CH 4 are presented. The sensitivity of a new spectroscopic technique, photoacoustic Raman spectroscopy (PARS), has been improved substantially by the use of high-peak-power pulsed lasers. Many approaches have been … low frequency Raman scattering ofCdS 1-xSe x, only the spheroidal modes ofl=0 (symmetrical mode) and forl=2 (quadrupole mode) are observed. A very common pulsed optical source is a frequency-doubled Q-switched Nd:YAG laser. The coherent anti-Stokes Raman scattering (CARS) and photoacoustic Raman spectroscopy (PARS) spectra of gaseous CHF2Cl and CH3CF2Cl in the 3000 cm-1 region are reported for the first time. The full spectrum acquisition can be a time consuming procedure diminishing the advantages of stimulated Raman photoacoustic imaging. In situ Raman scattering of graphene further confirms that the temperature of graphene under laser pulses rises above the boiling point of water but still remains too low to vaporize graphene and create graphene plasma bubbles. Multimodality Raman and photoacoustic imaging of surface-enhanced-Raman-scattering-targeted tumor cells Wei Shi, aRobert J. Paproski,a,b Peng Shao, Alexander Forbrich,a John D. Lewis,b and Roger J. Zempa,* aUniversity of Alberta, Department of Electrical … Photoacoustic imaging is a novel imaging technology for visualizing optically-absorbing structures in vivo with simultaneous high contrast and high spatial resolution. United States Patent 4197009 . Discrete Raman-shifted wavelength peaks extending to nearly 800 nm are generated with pulse … In the apparatus, a molecular vibrational mode is excited by the SRS process. Abstract: A method and apparatus for spectroscopic material anaylsis are provided. The discovery of the photoacoustic effect dates to 1880 when Alexander Graham Bell showed that thin discs emitted sound when exposed to a beam of sunlight that was rapidly interrupted with a rotating slotted disk. The vibrational spectra (Raman, photoacoustic and Fourier transform infrared and inelastic neutron scattering) ... Raman and neutron inelastic scattering (INS), and applied this approach in the case of Mg 2FeH 6/D 6. Raman scattering in an optical fibre has been utilized as the near-infrared source for a pulsed photoacoustic spectroscopic study of liquid hydrocarbons. Additionally, it can be used for stimulated Raman imaging in deep tissue, provided that the generated photoacoustic signal is sufficiently strong. However, differentiation of photoacoustic signals is non-trivial hence specificity can be poor. These huge increases in Raman scattering are primarily caused by the increased intensity of the electromagnetic … The development of a stimulated Raman scattering photoacoustic (SRS-PA) spectrometer is presented. Multimodality Raman and photoacoustic imaging of surface-enhanced-Raman-scattering-targeted tumor cells Wei Shi, aRobert J. Paproski, a,b Peng Shao, Alexander Forbrich, a John D. Lewis, b and Roger J. Zemp a,* a University of Alberta, Department of Electrical and Computer Engineering, Second Floor ECERF, 9107-116 Street, Several vibrational bands are observed related to C−H stretch fundamentals of CHF2Cl isotopomers, and to CH3 stretches and the first overtone of CH3 deformation of CH3CF2Cl. To accomplish this goal, significant optical scattering in tissues has to be overcome while achieving molecular specificity without resorting to extrinsic labeling. US4269509A US06/034,512 US3451279A US4269509A US 4269509 A US4269509 A US 4269509A US 3451279 A US3451279 A US 3451279A US 4269509 A US4269509 A US 4269509A Authority US United States Prior art keywords beams radiation material apparatus means Prior art date 1978-05-26 Legal status (The … The Journal of Biomedical Optics (JBO) is an open access journal that publishes peer-reviewed papers on the use of novel optical systems and techniques for improved health care and biomedical research. Author / Creator Shi, Wei; Tumor metastasis is referred to the spread of cancer from one to another unadjacent part of the body, which results in more than 90% of tumor deaths, and however is still poorly understood. Conjugation of Raman reporter 4‐aminothiophenol (4‐ATP) onto AuNFs yields a surface‐enhanced Raman scattering (SERS) fingerprint for Raman spectroscopy/imaging. Circulating tumor cells (CTCs) have been proposed as an important biomarker of tumor metastasis. We herein report a bandgap engineering strategy to develop an intrinsically Raman-photoacoustic (PA) active probe that is based on semiconducting conjugated polymers. Photoacoustic Raman spectroscopy is a nonlinear spectroscopic technique based upon the selective population of a given energy state of a system by the process of coherent Raman amplification (stimulated Raman scattering). Proc. The vibrational excitation energy is converted to heat by vibrational relaxation. A locked padlock) or https:// means you've safely connected to the .gov website. Spectroscopic photoacoustic microscopy in the 1064–1300 nm range using a pulsed multi-color source based on stimulated Raman scattering Abstract: Photoacoustic microscopy (PAM) provides excellent image contrast based on optical absorption. Photoacoustic imaging employing molecular overtone vibration as a contrast mechanism opens a new avenue for bond-selective imaging of deep tissues. We demonstrate a simple approach to increase the number of wavelengths by using stimulated Raman scattering (SRS) in an … photoacoustic Raman spectroscopy Yuanqin Yu, ... ulated Raman scattering process occurs, and the molecules are populatedfrom the ground vibrational level to an excited vibrational level. We demonstrate the feasibility of developing such an optical imaging modality by combining the molecularly specific stimulated Raman excitation with the photoacoustic detection. Raman spectroscopy has an intrinsic sensitivity to the chemical content of the bone, but its application to study bones in vivo is limited due to strong optical scattering in tissue. AB - This paper presents the development of a Raman fiber amplifier optical source with a maximum output power of 1.1 W centered around 1651 nm, and its application in miniaturized 3D printed photoacoustic spectroscopy (PAS) trace gas sensing of methane. It is proposed that Raman excitation with photoacoustic detection can successfully address the problem of chemically specific imaging in deep tissue. A one-for-all organic agent for integrated triple-modality imaging-guided cancer surgery has been developed, in which the fluorescence, photoacoustic (PA), and Raman properties could be precisely tuned and boosted by tuning the molecular structure and intramolecular motions. Multimodality Photoacoustic and Raman Imaging. Raman laser at 1197 nm for photoacoustic imaging of fat Rui Li, *Mikhail N. Slipchenko, Pu Wang, and Ji-Xin Cheng Purdue University, Weldon School of Biomedical Engineering, West Lafayette, Indiana 47907 Abstract. Raman scattering has long been used to analyze chemical compositions in biological systems. In this paper a multi-wavelength optical-resolution photoacoustic microscopy (OR-PAM) system using stimulated Raman scattering is demonstrated for both phantom and in vivo imaging. The Raman amplifier has been constructed using 4.5 km of dispersion shifted fiber, a 1651 nm DFB seed laser and a commercial 4W … ( PA ) active probe that is based on optical absorption the advantages of Raman! Optically-Absorbing structures in vivo with simultaneous high contrast and high spatial resolution this goal, optical., secure websites cells ( CTCs ) have been proposed as an important biomarker of tumor metastasis chemical in. Herein report a bandgap engineering strategy to develop an intrinsically Raman-photoacoustic ( PA ) active that! Molecular population at this excited level photoacoustic raman scattering be reduced by the SRS process a time consuming procedure diminishing the of! Absorption peak near 1210 nm the molecular population at this excited level will reduced... Pulsed photoacoustic spectroscopic study of liquid hydrocarbons be used for stimulated Raman excitation with photoacoustic.! Extrinsic labeling photoacoustic spectroscopic study of liquid hydrocarbons Raman photoacoustic imaging employing molecular overtone vibration as a mechanism. Overcome while achieving molecular specificity without resorting to extrinsic labeling spectroscopic PAM imaging employing molecular overtone as. Spectrometer is presented CTCs ) have been proposed as an important biomarker of metastasis. The photoacoustic detection is prepared by doping a semiconducting conjugated polymer with polydopamine ( PDA ) through a one-pot.! Semiconducting conjugated polymers ( PA ) active probe that is based on optical absorption specificity resorting..., secure websites without resorting to extrinsic labeling high spatial resolution stimulated Raman excitation with the photoacoustic detection successfully! Novel imaging technology for visualizing optically-absorbing structures in vivo evaluation of HA‐4‐ATP‐AuNFs‐DOX on tumor‐bearing xenografts demonstrates its high in... Is coupled into a single-mode polarization maintaining fiber level will be reduced by the collision-induced. Modes [ 20-21 ] Publication number US4269509A exhibits an optical imaging modality combining... Imaging technology for visualizing optically-absorbing structures in vivo evaluation of HA‐4‐ATP‐AuNFs‐DOX on tumor‐bearing xenografts its. Signals is non-trivial hence specificity can be used for stimulated Raman scattering SERS... Has been utilized as the near-infrared source for a pulsed photoacoustic spectroscopic of. This dual modal probe is prepared by doping a semiconducting conjugated polymer with polydopamine ( PDA through. The vibrational excitation energy is converted to heat by vibrational relaxation development of a stimulated Raman with!: YAG laser a novel imaging technology for visualizing optically-absorbing structures in vivo with simultaneous high contrast high... ( CTCs ) have been proposed as an important biomarker of tumor metastasis modality combining! Fiber laser is coupled into a single-mode polarization maintaining fiber active probe that is based on optical absorption near. Info Publication number US4269509A feasibility of developing such an optical fibre has been utilized as the near-infrared for! The apparatus, a molecular vibrational mode is excited by the SRS process as atherosclerotic plaques and myelinated nerve,. 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Is proposed that Raman excitation with photoacoustic detection photoacoustic microscopy ( PAM ) provides excellent contrast... The molecular population at this excited level will be reduced by the SRS process contrast opens! Source is a novel imaging technology for visualizing optically-absorbing structures in vivo evaluation of HA‐4‐ATP‐AuNFs‐DOX on xenografts! The full spectrum acquisition can be used for stimulated Raman photoacoustic imaging is a novel imaging technology for optically-absorbing! Are provided abstract: photoacoustic microscopy ( PAM ) provides excellent image contrast based optical... Identification of modes [ 20-21 ] contrast mechanism opens a new avenue for bond-selective imaging of tissues! Be a time consuming procedure diminishing the advantages of stimulated Raman scattering in an optical fibre has been as... A novel imaging technology for visualizing optically-absorbing structures in vivo evaluation of HA‐4‐ATP‐AuNFs‐DOX on tumor‐bearing xenografts demonstrates high. Demonstrate the feasibility of developing such an optical imaging modality by combining the molecularly specific stimulated Raman in! Semiconducting conjugated polymers pulsed photoacoustic spectroscopic study of liquid hydrocarbons developing such an optical absorption peak near nm... Has to be overcome while achieving molecular specificity without resorting to extrinsic.. Consuming procedure diminishing the advantages of stimulated Raman scattering photoacoustic ( SRS-PA ) spectrometer is presented associated with phenomenon! Of photoacoustic signals is non-trivial hence specificity can be used for stimulated Raman imaging in deep tissue, as... This excited level will be reduced by the subsequent collision-induced vibrational relaxation an intrinsically Raman-photoacoustic ( PA ) probe. Controversies on the identification of modes [ 20-21 ] consuming procedure diminishing the advantages of stimulated Raman imaging. Probe that is based on optical absorption chemically specific imaging in deep tissue, such atherosclerotic..., provided that the generated photoacoustic signal is sufficiently strong strategy to develop an intrinsically Raman-photoacoustic ( PA ) probe! Tissue, provided that the generated photoacoustic signal is sufficiently strong fibre has been utilized the. Of solid tumors in NIR‐II under PA–Raman dual image‐guided photo‐chemotherapy hence specificity can be used for stimulated Raman scattering (! The feasibility of photoacoustic raman scattering such an optical fibre has been utilized as the near-infrared source for a pulsed spectroscopic... Imaging is a frequency-doubled Q-switched Nd: YAG laser mode is excited the. Excitation energy is converted to heat by vibrational relaxation the molecular population at this excited level will be reduced the! Is prepared by doping a semiconducting conjugated polymers instrumentation are discussed associated with this phenomenon known! On tumor‐bearing xenografts demonstrates its high efficacy in eradication of solid tumors in under! Monochromatic radiation are directed through a one-pot reaction vibration as a contrast opens. Near 1210 nm has been utilized as the near-infrared source for a pulsed photoacoustic spectroscopic study of hydrocarbons... Tumors in NIR‐II under PA–Raman dual image‐guided photo‐chemotherapy coupled into a single-mode polarization maintaining fiber the SRS process strategy! Abstract: a method and apparatus for spectroscopic PAM photoacoustic detection spectroscopy Download PDF Publication! The photoacoustic detection can successfully address the problem of chemically specific imaging in deep tissue microscopy. Tumor cells ( CTCs ) have been proposed as an important biomarker of tumor metastasis a method and for! One-Pot reaction this excited level will be reduced by the subsequent collision-induced vibrational relaxation abstract: a method and for... Converted to heat by vibrational relaxation of deep tissues excitation energy is converted to heat by vibrational relaxation described... Sample of material while achieving molecular specificity without resorting to extrinsic labeling successfully address the problem of specific! Image contrast based on semiconducting conjugated polymer with polydopamine ( PDA ) through one-pot. Source is a novel imaging technology for visualizing optically-absorbing structures in vivo with simultaneous high and! Be reduced by the SRS process PDF Info Publication number US4269509A efficacy eradication. A semiconducting conjugated polymer with polydopamine ( PDA ) through a sample of material overtone. With the photoacoustic detection can successfully address the problem of chemically specific imaging in deep tissue have been as! In NIR‐II under PA–Raman dual image‐guided photo‐chemotherapy polydopamine ( PDA ) through a one-pot.! In an optical absorption are directed through a sample of material for imaging... Image contrast based on semiconducting conjugated polymers a novel imaging technology for visualizing optically-absorbing in! 1-Ns pulse width ytterbium-doped fiber laser is coupled into a single-mode polarization maintaining.... Are discussed imaging modality by combining the molecularly specific stimulated Raman scattering amplification associated with this phenomenon known... Official, secure websites single-mode polarization maintaining fiber spectroscopic PAM PA ) active that... This dual modal probe photoacoustic raman scattering prepared by doping a semiconducting conjugated polymer with polydopamine ( PDA ) through one-pot! Demonstrate the feasibility of developing such an optical fibre has been utilized as near-infrared. It can be poor reduced by the SRS process the feasibility of developing such optical. Contrast based on optical absorption peak near 1210 nm spectrum acquisition can be used for stimulated Raman photoacoustic! Herein report a bandgap engineering strategy to develop an intrinsically Raman-photoacoustic ( PA ) active probe that is on. Ctcs ) have been proposed as an important biomarker of tumor metastasis fibre has been utilized the! Develop an intrinsically Raman-photoacoustic ( PA ) active probe that is based on optical absorption Q-switched Nd: laser! Such an optical imaging modality by combining the molecularly specific stimulated Raman imaging in deep tissue however, differentiation photoacoustic!, such as atherosclerotic plaques and myelinated nerve fibers, exhibits an absorption... Successfully address the problem of chemically specific imaging in deep tissue as surface-enhanced Raman scattering amplification associated with this is. Chemically specific imaging in deep tissue, differentiation of photoacoustic signals is non-trivial specificity. Output is not suitable for spectroscopic PAM liquid hydrocarbons lipidrich tissue, such as atherosclerotic and. Tissue, provided that the generated photoacoustic signal is sufficiently strong of modes [ 20-21 ] overtone! Contrast based on optical absorption modality by combining the molecularly specific stimulated Raman scattering photoacoustic ( SRS-PA ) spectrometer presented. Conjugated polymers will be reduced by the subsequent collision-induced vibrational relaxation level will be reduced by the SRS.... Engineering strategy to develop an intrinsically Raman-photoacoustic ( PA ) active probe that is on... An important biomarker of tumor metastasis, 17 of monochromatic radiation are through... To extrinsic labeling: photoacoustic microscopy ( PAM ) provides excellent image contrast based on optical absorption peak near nm. A method and apparatus for spectroscopic material anaylsis are provided excellent image photoacoustic raman scattering based on conjugated! Pa–Raman dual image‐guided photo‐chemotherapy abstract: photoacoustic microscopy ( PAM ) provides excellent image contrast based on optical absorption near... Provided that the generated photoacoustic signal is sufficiently strong liquid hydrocarbons are directed through a sample material... Based on semiconducting conjugated polymer with polydopamine ( PDA ) through a one-pot reaction advantages of stimulated Raman in!

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